SYNTHESES OF DEUTERIUM-LABELED METHYL BRANCHED FATTY-ACIDS

被引：7

作者：

DOBNER, B ^{[1
]}

NUHN, P ^{[1
]}

机构：

[1] UNIV HALLE,DEPT PHARM,O-4020 HALLE,GERMANY

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1991年 / 60卷 / 01期

关键词：

DEUTERIUM; BRANCHED; FATTY ACIDS; 2-ALKYL-OMEGA-HYDROXY-CARBOXYLIC ACIDS;

D O I：

10.1016/0009-3084(91)90011-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The syntheses of some trideuterated methyl branched fatty acids. suitable for NMR-studies in membranes, are described by successive reductions of an ester carbonyl group. Two methods were found to prepare 2-alkyl-omega-hydroxy carboxylic acids which are suitable intermediates for the syntheses of the title compounds.

引用

收藏

页码：21 / 28

页数：8

相关论文

共 12 条

[1] REACTIONS OF ALIPHATIC METHANESULFONATES .I. SYNTHESES OF LONG-CHAIN GLYCERYL-(1) ETHERS [J].

BAUMANN, WJ ;

MANGOLD, HK .

JOURNAL OF ORGANIC CHEMISTRY, 1964, 29 (10) :3055-&

[2]

BICKELHAUPT F, 1988, SYNTHESIS APPLICATIO, P717

[3] INFLUENCE OF ALPHA-BRANCHED FATTY-ACID CHAINS ON THE THERMOTROPIC BEHAVIOR OF 1-O-ACYL-2-O-HEXADECYL-GLYCEROPHOSPHOCHOLINES [J].

BREZESINSKI, G ;

DOBNER, B ;

DORFLER, HD ;

FISCHER, M ;

HAAS, S ;

NUHN, P .

CHEMISTRY AND PHYSICS OF LIPIDS, 1987, 43 (04) :257-264

[4]

CREGER PL, 1970, J AM CHEM SOC, V92, P1397

[5] SYNTHESES OF DEUTERIUM-LABELLED PRISTANIC AND PHYTANIC ACIDS [J].

JOHNSON, DW ;

POULOS, A .

CHEMISTRY AND PHYSICS OF LIPIDS, 1988, 48 (1-2) :141-146

[6] MICROBIOLOGICAL OXIDATION OF LONG-CHAIN ALIPHATIC COMPOUNDS .2. BRANCHED-CHAIN ALKANES [J].

JONES, DF .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1968, (22) :2809-&

[7] THERMOTROPIC PROPERTIES OF SYNTHETIC CHAIN-SUBSTITUTED PHOSPHATIDYLCHOLINES - EFFECT OF SUBSTITUENT SIZE, POLARITY, NUMBER, AND LOCATION ON MOLECULAR PACKING IN BILAYERS [J].

MENGER, FM ;

WOOD, MG ;

ZHOU, QZ ;

HOPKINS, HP ;

FUMERO, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (20) :6804-6810

[8] SYNTHESIS, CALORIMETRY, AND X-RAY-DIFFRACTION OF LECITHINS CONTAINING BRANCHED FATTY-ACID CHAINS [J].

NUHN, P ;

BREZESINSKI, G ;

DOBNER, B ;

FORSTER, G ;

GUTHEIL, M ;

DORFLER, HD .

CHEMISTRY AND PHYSICS OF LIPIDS, 1986, 39 (03) :221-236

[9]

SALMONLE.F, 1965, B SOC CHIM FR, P2270

[10] EFFECTS OF PHOSPHOLIPID ACYL CHAIN STRUCTURE ON PHYSICAL-PROPERTIES .1. ISOBRANCHED PHOSPHATIDYLCHOLINES [J].

SILVIUS, JR ;

MCELHANEY, RN .

CHEMISTRY AND PHYSICS OF LIPIDS, 1979, 24 (03) :287-296