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ANALYSIS OF GENES AND CHROMOSOMES BY NONISOTOPIC INSITU HYBRIDIZATION

被引：224
作者：
LICHTER, P
BOYLE, AL
CREMER, T
WARD, DC
机构：
[1] INST HUMAN GENET & ANTHROPOL, HEIDELBERG, GERMANY
[2] YALE UNIV, SCH MED, DEPT HUMAN GENET, NEW HAVEN, CT 06510 USA
[3] YALE UNIV, SCH MED, DEPT MOLEC BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA
来源：
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING | 1991年 / 8卷 / 01期
关键词：
D O I：
10.1016/1050-3862(91)90005-C
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Nonisotopic in situ hybridization is a powerful tool to analyze the organization of complex genomes. Current approaches utilizing this technique for the analysis of linear and spatial genome organizations are presented. Clinical applications of these approaches, which open new avenues for diagnosis of disease-related chromosomal changes, are also discussed.
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页码：24 / 35
页数：12
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