PEPTIDE NUCLEIC-ACIDS AND THEIR POTENTIAL APPLICATIONS IN BIOTECHNOLOGY

被引：118

作者：

BUCHARDT, O

EGHOLM, M

BERG, RH

NIELSEN, PE

机构：

[1] PANUM INST,DEPT MED BIOCHEM & GENET,MED BIOCHEM LAB,DK-2200 COPENHAGEN,DENMARK

[2] RISO NATL LAB,DEPT MAT,POLYMER GRP,DK-4000 ROSKILDE,DENMARK

来源：

TRENDS IN BIOTECHNOLOGY | 1993年 / 11卷 / 09期

关键词：

D O I：

10.1016/0167-7799(93)90097-S

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Peptide nucleic acids (PNAs) are novel DNA mimics in which the sugar-phosphate backbone has been replaced with a backbone based on amino acids1-3. PNAs exhibit sequence-specific binding to DNA and RNA with higher affinities and specificities than unmodified DNA. They,are resistant to nuclease and protease attack in serum and cellular extracts and, thus, appear very promising as diagnostic and biomolecular probes, and possibly as antisense and antigene drugs.

引用

页码：384 / 386

页数：3