HYPOGLYCEMIC ACTIVITY AND MECHANISMS OF EXTRACTS FROM MULBERRY LEAVES (FOLIUM-MORI) AND CORTEX-MORI-RADICIS IN STREPTOZOTOCIN-INDUCED DIABETIC MICE

被引:87
作者
CHEN, FJ [1 ]
NAKASHIMA, N [1 ]
KIMURA, I [1 ]
KIMURA, M [1 ]
机构
[1] TOYAMA MED & PHARMACEUT UNIV, FAC PHARMACEUT SCI, DEPT CHEM PHARMACOL, TOYAMA 93001, JAPAN
来源
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1995年 / 115卷 / 06期
关键词
STREPTOZOTOCIN-INDUCED DIABETIC MOUSE; FOLIUM MORI (MULBERRY LEAVE); CORTEX MORI RADICIS; BLOOD GLUCOSE LEVEL; HYPOGLYCEMIC EFFECT;
D O I
10.1248/yakushi1947.115.6_476
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Averaged blood glucose levels were 400 mg/dl in nonfasted mice, and 250 mg/dl in fasted mice in 4 weeks after injection with streptozotocin (STZ, 150 mg/kg, i.v.). These mice were used for experiments. Hypoglycemic effects of hot water extracts (W) from Folium Mori (Mulberry leaves, Morus alba L., China and Japan) or Cortex Mori Radicis (Morus alba L., China) were observed in fasted and nonfasted STZ-induced diabetic mice at a single dose of 200 mg/kg (i.p.). The W from Folium Mori exhibited most potent hypoglycemic effects. The most potent fractions of Folium Mori and Cortex Mori Radicis were ethanol-insoluble extracts (A2). These A2 fractions demonstrated a fall in blood glucose levels of 24.6+/-6.0% and 60.5+/-9.1% at nonfasted STZ-mice, and 81.4+/-7.9% and 77.3+/-5.8% at fasted STZ-mice, respectively. The increase in glucose uptake was a mechanism of hypoglycemic actions by W and A2 of Folium Mori.
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收藏
页码:476 / 482
页数:7
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