HEMISPHERIC-ASYMMETRY IN BEHAVIORAL-RESPONSE TO D1-RECEPTOR AND D2-RECEPTOR AGONISTS IN THE NUCLEUS-ACCUMBENS

被引：24

作者：

BELCHEVA, I

BRYER, JB

STARKSTEIN, SE

HONIG, M

MORAN, TH

ROBINSON, RG

机构：

[1] UNIV IOWA,DEPT PSYCHIAT,IOWA CITY,IA 52242

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

来源：

BRAIN RESEARCH | 1990年 / 533卷 / 02期

关键词：

Asymmetry; Dopamine; Lateralization; Locomotion; Nucleus accumbens;

D O I：

10.1016/0006-8993(90)91351-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the locomotor response of rats unilateral injections of the mixed D1/D2 agonist apomorphine, the D2 agonist quinpirole, and the D1 agonist SKF 38393 into the left or right nucleus accumbens (NA) of male Sprague-Dawley rats. There were 2 main findings. First, unilateral (left or right) injections of apomorphine, quinpirole, or SKF 38393 all provoked locomotor hyperactivity. The second and more important finding was that, at specific dosages, apomorphine and SKF 38393 injections into the right NA produced significantly more locomotor hyperactivity than identical injections into the left NA. These findings suggest the presence of asymmetries in the NA which may involve quantitative differences in the distribution of D1 and D2 receptors. © 1990.

引用

页码：286 / 291

页数：6

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