TOWARD ELUCIDATION OF THE INHIBITION-MECHANISM OF PHOSPHOLIPASE-A2 BY MANOALIDE - SELECTIVELY MODIFIED AMINO-ACID-RESIDUES BY MANOALIDE ANALOGS

被引：15

作者：

KATSUMURA, S

HAN, Q

FUJIWARA, S

ISOE, S

NISHIMURA, H

INOUE, S

IKEDA, K

机构：

[1] OSAKA CITY UNIV,FAC SCI,OSAKA 558,JAPAN

[2] OSAKA UNIV PHARMACEUT SCI,DEPT BIOCHEM,MATSUBARA,OSAKA 580,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80227-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Manoalide and seco-manoalide analogues synthesized from geranyl chloride selectively modified only two of eleven lysine residues of bovine pancreatic phospholipase A2.

引用

页码：1267 / 1268

页数：2

共 4 条

[1] INACTIVATION OF PHOSPHOLIPASE-A2 BY MANOALIDE - LOCALIZATION OF THE MANOALIDE BINDING-SITE ON BEE VENOM PHOSPHOLIPASE-A2 [J].

GLASER, KB ;

VEDVICK, TS ;

JACOBS, RS .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (19) :3639-3646

[2] TOWARD ELUCIDATION OF THE INHIBITION-MECHANISM OF PHOSPHOLIPASE-A2 BY MANOALIDE - SELECTIVELY MODIFIED AMINO-ACID-RESIDUES BY MANOALIDE ANALOGS [J].

KATSUMURA, S ;

HAN, Q ;

FUJIWARA, S ;

ISOE, S ;

NISHIMURA, H ;

INOUE, S ;

IKEDA, K .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (10) :1267-1268

[3]

LAMBARDO S, 1985, J BIOL CHEM, V260, P7234

[4]

LAYNOLDS LJ, 1991, J BIOL CHEM, V266, P16512

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