METABOLIC-ACTIVATION OF THE SEROTONERGIC NEUROTOXIN PARA-CHLOROAMPHETAMINE TO CHEMICALLY REACTIVE INTERMEDIATES BY HEPATIC AND BRAIN MICROSOMAL PREPARATIONS

被引:21
作者
MILLER, KJ [1 ]
ANDERHOLM, DC [1 ]
AMES, MM [1 ]
机构
[1] MAYO CLIN & MAYO FDN,DEPT ONCOL,DIV DEV ONCOL RES,ROCHESTER,MN 55905
关键词
D O I
10.1016/0006-2952(86)90332-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1737 / 1742
页数:6
相关论文
共 40 条
[1]   STEREOCHEMICAL ASPECTS OF PARA-CHLOROAMPHETAMINE METABOLISM - RABBIT LIVER MICROSOMAL METABOLISM OF RS-, R(-)-, AND S(+)-PARA-CHLOROAMPHETAMINE [J].
AMES, MM ;
FRANK, SK .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (01) :5-9
[2]  
AMES MM, 1977, COMMUN PSYCHOPHARMAC, V1, P455
[3]  
BAUMGARTEN HG, 1976, ACTA PHYSL SCAND, V391, P3
[4]   METABOLISM OF AMPHETAMINES IN MAMMALS [J].
CALDWELL, J .
DRUG METABOLISM REVIEWS, 1976, 5 (02) :219-280
[5]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578
[6]  
CLEMENS JA, 1978, COMMUN PSYCHOPHARMAC, V2, P11
[7]   INHIBITION BY CO OF HEPATIC BENZO[A]PYRENE HYDROXYLATION AND ITS REVERSAL BY MONOCHROMATIC LIGHT [J].
COOPER, DY ;
SCHLEYER, H ;
ROSENTHAL, O ;
LEVIN, W ;
LU, AYH ;
KUNTZMAN, R ;
CONNEY, AH .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 74 (01) :69-75
[8]  
CREVELING CR, 1975, CHEMICAL TOOLS CATEC, V1, P23
[9]  
DAS M, 1981, J PHARMACOL EXP THER, V216, P156
[10]   METABOLISM OF POLYCYCLIC-HYDROCARBONS AND ITS RELATIONSHIP TO CANCER [J].
DEPIERRE, JW ;
ERNSTER, L .
BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 473 (3-4) :149-186