MICRO-FFF - THEORETICAL AND PRACTICAL ASPECTS OF REDUCING THE DIMENSIONS OF FIELD-FLOW FRACTIONATION CHANNELS

被引：18

作者：

GIDDINGS, JC

机构：

[1] Field-Flow Fractionation Research Center, Department of Chemistry, University of Utah, Salt Lake City, Utah

来源：

JOURNAL OF MICROCOLUMN SEPARATIONS | 1993年 / 5卷 / 06期

关键词：

FIELD-FLOW FRACTIONATION; MICROCOLUMN FFF; FFF CHANNEL DIMENSIONS;

D O I：

10.1002/mcs.1220050602

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The value of miniaturizing field-flow fractionation (FFF) channels is examined based on theoretical and experimental evidence. While FFF and chromatography are dynamically similar, the dimension analogous to capillary or particle diameter in chromatography is the Brownian excursion distance (l), a ''soft'' dimension controlled by field strength and thus subject to significant reduction by increasing the field strength. Optimization of the 'hard' channel dimensions (length, breadth, thickness) is a more complex matter involving diverse factors including sample dilution and detectability, clog-free operation, edge effects, relaxation time, compatibility with pump and detector systems, and only in some cases the influence of these dimensions on the achievable l.

引用

页码：497 / 503

页数：7

共 22 条

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