COGNITIVE-DEVELOPMENT OF YU-CHENG (OIL DISEASE) CHILDREN PRENATALLY EXPOSED TO HEAT-DEGRADED PCBS

被引:203
作者
CHEN, YCJ
GUO, YL
HSU, CC
ROGAN, WJ
机构
[1] NATL CHENG KUNG UNIV,COLL MED,DEPT ENVIRONM HLTH,TAINAN,TAIWAN
[2] NIEHS,RES TRIANGLE PK,NC 27709
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1992年 / 268卷 / 22期
关键词
D O I
10.1001/jama.268.22.3213
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective.-To compare the cognitive development in Taiwanese children who had been exposed prenatally to high levels of heat-degraded polychlorinated biphenyls (PCBs) with control children who were exposed to background levels. The disorder was called Yu-Cheng, "oil disease," in Taiwan. Design.-Matched-pair cohort study. Setting.-Communities in central Taiwan in which there had been a cooking-oil contamination and mass poisoning by heat-degraded PCBs in 1978 through 1979. Participants.-One hundred eighteen children born between June 1978 and March 1985 during or after their mothers' consumption of contaminated rice oil; 118 children matched for age, sex, neighborhood, maternal age, and parental education and occupational class; and 15 older siblings of exposed children, born before the poisoning. Main Outcome Measures.-Cognitive development measured from 1985 through 1990 using the Chinese versions of the Stanford-Binet test and the Wechsler Intelligence Scale for Children, Revised. Results.-The exposed children scored approximately 5 points lower on the Stanford-Binet test at the ages of 4 and 5 years and approximately 5 points lower on the Wechsler Intelligence Scale for Children, Revised, at the ages of 6 and 7 years. Children born up to 6 years after their mothers' exposure were as affected as children born within a year or two after exposure when examined at 6 and 7 years of age. Older siblings resembled the control children. Conclusion.-Children prenatally exposed to heat-degraded PCBs had poorer cognitive development than their matched controls. The effect persisted in the children up to the age of 7 years, and children born long after the exposure were still affected.
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页码:3213 / 3218
页数:6
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