XECL LASER ABLATION OF ATHEROSCLEROTIC AORTA - OPTICAL-PROPERTIES AND ENERGY PATHWAYS

被引:46
作者
ORAEVSKY, AA
JACQUES, SL
PETTIT, GH
SAIDI, IS
TITTEL, FK
HENRY, PD
机构
[1] RICE UNIV,DEPT ELECT & COMP ENGN,HOUSTON,TX 77251
[2] BAYLOR COLL MED,DIV CARDIOL,HOUSTON,TX 77030
[3] US FDA,CTR DEVICES & RADIOL HLTH,ROCKVILLE,MD 20857
[4] USSR ACAD SCI,INST SPECT,MOSCOW,USSR
关键词
TISSUE ABLATION; XECL EXCIMER LASER; TISSUE OPTICAL PROPERTIES; HUMAN AORTA;
D O I
10.1002/lsm.1900120604
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The energetics of 308-nm excimer laser irradiation of human aorta were studied. The heat generation that occurred during laser irradiation of atherosclerotic aorta equaled the absorbed laser energy minus the fraction of energy for escaping fluorescence (0.8-1.6%) and photochemical decomposition (2%). The absorbed laser energy is equal to the total delivered light energy minus the energy lost as specular reflectance (2.4%, air/tissue) and diffuse reflectance (11.5-15.5%). Overall, about 79-83.5% of the delivered light energy was converted to heat. We conclude that the mechanism of XeCl laser ablation of soft tissue involves thermal overheating of the irradiated volume with subsequent explosive vaporization. The optical properties of normal wall of human aorta and fibrous plaque, both native and denatured were determined. The light scattering was significant and sufficient to cause a subsurface fluence (J/cm2) in native aorta that equaled 1.8 times the broad-beam radiant exposure, PHI(o) (2.7PHI(o) for denatured aorta). An optical fiber must have a diameter of at least 800 mum to achieve a maximum light penetration (almost-equal-to 200 mum for PHI(o)/e) in the aorta along the central axis of the beam.
引用
收藏
页码:585 / 597
页数:13
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