SERUM CREATINE-KINASE MM ISOFORMS IN HYPERTROPHIC CARDIOMYOPATHY

被引：7

作者：

HAMADA, M ^{[1
]}

OHTANI, T ^{[1
]}

SEKIYA, M ^{[1
]}

FUJIWARA, Y ^{[1
]}

SUMIMOTO, T ^{[1
]}

HIWADA, K ^{[1
]}

MORITA, S ^{[1
]}

TSUKADA, H ^{[1
]}

机构：

[1] SRL CO LTD, DEPT LAB, TOKYO, JAPAN

来源：

CLINICAL SCIENCE | 1991年 / 81卷 / 06期

关键词：

CREATINE KINASE; HYPERTROPHIC CARDIOMYOPATHY; MM ISOFORMS;

D O I：

10.1042/cs0810723

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. To determine whether a persistent release of creatine kinase from the myocardium occurs in patients with hypertrophic cardiomyopathy, the activities of serum creatine kinase MM isoforms were measured in 22 patients with hypertrophic cardiomyopathy and in 14 normal control subjects. 2. Serum creatine kinase MB activity was significantly higher in patients with hypertrophic cardiomyopathy (7.8 +/- 3.8 i.u./l) than in normal control subjects (0.4 +/- 0.8 i.u./l; P < 0.01). 3. Serum MMa, MMb and MMc activities in patients with hypertrophic cardiomyopathy were 19.4 +/- 4.1%, 26.7 +/- 2.5% and 33.5 +/- 7.0% of the total creatine kinase MM activity, respectively. These values for each isoform were significantly different from those in normal control subjects (11.3 +/- 3.0%, 21.5 +/- 4.4% and 40.7 +/- 7.0%, respectively). The MMa/MMc activity ratio was significantly higher in patients with hypertrophic cardiomyopathy (0.61 +/- 0.25) than in normal control subjects (0.30 +/- 0.10; P < 0.01). 4. Our results indicate that a small amount of the myocardial tissue isoform of creatine kinase MM (MMa) is constantly released in many patients with hypertrophic cardiomyopathy.

引用

页码：723 / 726

页数：4