SHORT-TERM COCAINE SELF-ADMINISTRATION ALTERS STRIATAL GENE-EXPRESSION

被引：37

作者：

DAUNAIS, JB

ROBERTS, DCS

MCGINTY, JF

机构：

[1] E CAROLINA UNIV,SCH MED,DEPT ANAT & CELL BIOL,GREENVILLE,NC 27858

[2] CARLETON UNIV,DEPT PSYCHOL,OTTAWA,ON K1S 5B6,CANADA

来源：

BRAIN RESEARCH BULLETIN | 1995年 / 37卷 / 05期

关键词：

DOPAMINE; PREPRODYNORPHIN; ZIF/268; C-FOS; IN SITU HYBRIDIZATION; NUCLEUS ACCUMBENS;

D O I：

10.1016/0361-9230(95)00049-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats self-administered cocaine or received saline during 3 daily 5 h sessions and were euthanized 1 h after the final session. Quantitative in situ hybridization revealed that cocaine self-administration increased levels of preprodynorphin, but not preproenkephalin, c-fos, or zif/268 mRNAs in a patchy pattern in the dorsal striatum. These data demonstrate that the regulation of preprodynorphin gene expression is dissociable from that of c-fos and zif/268 in dorsal striatum following short-term cocaine self-administration.

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收藏

页码：523 / 527

页数：5

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