DIRADICAL NITROXYL SPIN LABEL CONTRAST AGENTS FOR MAGNETIC-RESONANCE-IMAGING - A COMPARISON OF RELAXATION EFFECTIVENESS

被引:24
作者
EHMAN, RL
BRASCH, RC
MCNAMARA, MT
ERIKKSON, U
SOSNOVSKY, G
LUKSZO, J
LI, SW
机构
[1] UNIV CALIF SAN FRANCISCO, DEPT RADIOL, CONTRAST MEDIA LAB, ROOM C-309, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USA
[3] UNIV WISCONSIN, DEPT CHEM, MADISON, WI 53706 USA
关键词
D O I
10.1097/00004424-198602000-00008
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The proton relaxation enhancement characteristics of seven potential MRI contrast agents containing two nitroxyl spin labels per molecule (diradicals) were compared with eight similar agents with only one spin label per molecule (monoradicals). Diradical nitroxyls were evaluated to test the hypothesis that multiple paramagnetic centers in one molecule will result in stronger proton relaxation enhancement characteristics, allowing effective contrast enhancement at lower molar concentrations and thus a reduced osmotic load and greater safety. The acute toxicity of these agents is believed to be largely related to osmotic load. Five of seven diradical nitroxyls tested had spin-lattice relaxivities that were substantially greater than all eight of the monoradicals tested. The spin-spin relaxation properties of these agents and other pertinent characteristics are favorable for contrast enhancement. The results indicate that diradical nitroxyl spin labels may be used advantageously for the design of safer, more effective MRI contrast agents.
引用
收藏
页码:125 / 131
页数:7
相关论文
共 29 条
[21]   POTENTIAL ORAL AND INTRAVENOUS PARAMAGNETIC NMR CONTRAST AGENTS [J].
RUNGE, VM ;
STEWART, RG ;
CLANTON, JA ;
JONES, MM ;
LUKEHART, CM ;
PARTAIN, CL ;
JAMES, AE .
RADIOLOGY, 1983, 147 (03) :789-791
[22]   INTRAVASCULAR CONTRAST AGENTS SUITABLE FOR MAGNETIC-RESONANCE IMAGING [J].
RUNGE, VM ;
CLANTON, JA ;
HERZER, WA ;
GIBBS, SJ ;
PRICE, AC ;
PARTAIN, CL ;
JAMES, AE .
RADIOLOGY, 1984, 153 (01) :171-176
[23]  
SPECK U, 1983, CONTRAST MEDIA UROGR, P2
[24]   RAPID CHROMATOGRAPHIC TECHNIQUE FOR PREPARATIVE SEPARATIONS WITH MODERATE RESOLUTION [J].
STILL, WC ;
KAHN, M ;
MITRA, A .
JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (14) :2923-2925
[25]   CHARACTERISTICS OF GADOLINIUM-DTPA COMPLEX - A POTENTIAL NMR CONTRAST AGENT [J].
WEINMANN, HJ ;
BRASCH, RC ;
PRESS, WR ;
WESBEY, GE .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1984, 142 (03) :619-624
[26]   TRANSLATIONAL MOLECULAR SELF-DIFFUSION IN MAGNETIC-RESONANCE IMAGING .1. EFFECTS ON OBSERVED SPIN-SPIN RELAXATION [J].
WESBEY, GE ;
MOSELEY, ME ;
EHMAN, RL .
INVESTIGATIVE RADIOLOGY, 1984, 19 (06) :484-490
[27]   EFFECT OF GADOLINIUM-DTPA ON THE MAGNETIC-RELAXATION TIMES OF NORMAL AND INFARCTED MYOCARDIUM [J].
WESBEY, GE ;
HIGGINS, CB ;
MCNAMARA, MT ;
ENGELSTAD, BL ;
LIPTON, MJ ;
SIEVERS, R ;
EHMAN, RL ;
LOVIN, J ;
BRASCH, RC .
RADIOLOGY, 1984, 153 (01) :165-169
[28]   NUCLEAR MAGNETIC-RESONANCE CONTRAST ENHANCEMENT STUDY OF THE GASTROINTESTINAL-TRACT OF RATS AND A HUMAN VOLUNTEER USING NONTOXIC ORAL IRON SOLUTIONS [J].
WESBEY, GE ;
BRASCH, RC ;
ENGELSTAD, BL ;
MOSS, AA ;
CROOKS, LE ;
BRITO, AC .
RADIOLOGY, 1983, 149 (01) :175-180
[29]   TRANSLATIONAL MOLECULAR SELF-DIFFUSION IN MAGNETIC-RESONANCE IMAGING .2. MEASUREMENT OF THE SELF-DIFFUSION COEFFICIENT [J].
WESBEY, GE ;
MOSELEY, ME ;
EHMAN, RL .
INVESTIGATIVE RADIOLOGY, 1984, 19 (06) :491-498