LIVER LIPOXYGENASE ARACHIDONIC-ACID METABOLITES IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS

被引：10

作者：

ROSELLOCATAFAU, J

HOTTER, G

CLOSA, D

ORTIZ, MA

POUTORELLO, JM

GIMENO, M

BIOQUE, G

GELPI, E

机构：

[1] HOSP SANTA CRUZ & SAN PABLO,DEPT ENDOCRINOL,BARCELONA,SPAIN

[2] CONSEJO NACL INVEST CIENT & TECN,CTR ESTUDIOS FARMACOL & BOT,BUENOS AIRES,DF,ARGENTINA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1994年 / 51卷 / 06期

关键词：

D O I：

10.1016/0952-3278(94)90057-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have studied the liver 15-hydroxyeicosatetraenoic acid (15-HETE) and leukotriene B-4 (LTB(4)) levels in streptozotocin- (ST)-induced diabetes in rats using liquid chromatography and radioimmunological techniques. Diabetic rats showed significant alterations of liver lipoxygenase metabolites when compared to controls, These 15-HETE and LTB(4) increases were concomitant with raised levels of plasma and tissue thromboxane B-2 (TXB(2)) and also urinary 2,3-dinor-TXB(2) in plasma and urine, respectively. These changes confirm an activation of 5- and 15-lipoxygenase in the liver 3 days after i.p. ST administration.

引用

页码：411 / 413

页数：3

共 15 条

[11] INCREASED RENAL TXA2 SYNTHESIS IN DIABETES-MELLITUS - SIMULTANEOUS DETERMINATION OF URINARY TXB2 AND 2,3-DINOR-TXB2 [J].