Transgenic and knock-out models for studying DNA repair

被引：9

作者：

Allemand, I

Angulo, JF

机构：

[1] Laboratoire de Génétique de la Radiosensibilité, Département de Radiobiologie et de Radiopathologie, Direction des Sciences du Vivant, Commissariat à l'Energie Atomique, CEN-FAR, BP 6

来源：

BIOCHIMIE | 1995年 / 77卷 / 10期

关键词：

transgenic models; knock-out mice; DNA repair; cell cycle;

D O I：

10.1016/0300-9084(96)88202-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transgenic animal technology, and especially the use of germ line manipulation for gene targeting, offers new strategies for in vivo analysis of the mechanisms of DNA repair and cell cycle control underlying their efficiency. In vivo risk assessment of genotoxic agents is already facilitated by using transgenic mice. Knock-out mice provide an opportunity to study the function of the disrupted gene, to model human diseases related to this inactivation, and to determine the consequences of loss of function after a genotoxic exposure. These models might also allow the development of new gene therapy strategies.

引用

页码：826 / 832

页数：7