DISTRIBUTION, METABOLISM, AND EXCRETION OF MUSK XYLENE IN RATS

被引：49

作者：

MINEGISHI, K ^{[1
]}

NAMBARU, S ^{[1
]}

FUKUOKA, M ^{[1
]}

TANAKA, A ^{[1
]}

NISHIMAKIMOGAMI, T ^{[1
]}

机构：

[1] NATL INST HYG SCI,DIV BIOL CHEM & BIOCHEM,TOKYO 158,JAPAN

来源：

ARCHIVES OF TOXICOLOGY | 1991年 / 65卷 / 04期

关键词：

ARTIFICIAL FRAGRANCE; MUSK XYLENE; METABOLISM (RAT); DISTRIBUTION; METABOLITES;

D O I：

10.1007/BF01968961

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Distribution, metabolism and excretion of musk xylene (MX) were investigated in male Wistar rats. Urinary and fecal excretion accounted for 10 and 75% of the dose (70 mg/kg), respectively, on day 7 after orally administration of H-3-MX to rats. Total residue of radioactivity in tissues on day 7 was less than 2.0% of the administered dose. The highest concentration was found in adipose tissue and the second was in liver. Some metabolites of MX were identified using GC-MS and NMR after purification by column or thin layer chromatography of feces, bile and urine extracts. MX, 2-NH2-MX, 2-Ac-MX, 2-NH2-3-CH2OH-MX, and 2-NH2-5-tert-BuOH-MX were found in feces, bile and urine. 4-NH2-MX and metabolite X were found in feces and urine. 4-NH2-3-CH2OH-MX was found in urine. HO-MX was found in bile. The major route of excretion for MX was the feces via bile. The reduction of the 2-nitro group of MX to the amino group was a key step in metabolism. Further metabolism of 2-NH2-MX may proceed by decreased steric hindrance of functional group.

引用

页码：273 / 282

页数：10

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