C-ERBB-2 GENE-PRODUCT DIRECTLY ASSOCIATES WITH BETA-CATENIN AND PLAKOGLOBIN

被引：147

作者：

KANAI, Y ^{[1
]}

OCHIAI, A ^{[1
]}

SHIBATA, T ^{[1
]}

OYAMA, T ^{[1
]}

USHIJIMA, S ^{[1
]}

AKIMOTO, S ^{[1
]}

HIROHASHI, S ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,DIV PATHOL,CHUO KU,TOKYO 104,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 208卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1443

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Association of the c-erbB-2 oncogene product with the cadherin-catenin complex has been demonstrated in human cancer cell lines. Although beta-catenin and plakoglobin have been proven to be crucial for the association, no previous study has shown whether the interactions are direct or indirect. In the present study, the c-erbB-2 gene product was shown by far-Western blotting analysis to associate directly with both beta-catenin and plakoglobin through its cytoplasmic domain core region, which showed extensive homology with epidermal growth factor receptor. These data suggest that c-erbB-2-induced signaling is also directly liked to the cadherin-mediated cell adhesion and ''invasion-suppressor'' system through beta-catenin and plakoglobin in cancers. (C) 1995 Academic Press, Inc.

引用

页码：1067 / 1072

页数：6

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