MOUSE HOX GENETIC FUNCTIONS

被引：49

作者：

KRUMLAUF, R ^{[1
]}

机构：

[1] NATL INST MED RES, DEV NEUROBIOL LAB, LONDON NW7 1AA, ENGLAND

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/0959-437X(93)90098-A

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Functional analysis of the genetic roles of the mammalian Hox homeobox family has not been facilitated by the analysis of disease-associated or classically derived mutant loci. However, an increasing number of mouse Hox mutations, generated by homologous recombination, have now demonstrated that the Hox genes are key components in regulating the patterning of axial structures.

引用

页码：621 / 625

页数：5

共 46 条

[1]

AKAM M, 1987, DEVELOPMENT, V101, P1

[2] HOX AND HOM - HOMOLOGOUS GENE CLUSTERS IN INSECTS AND VERTEBRATES [J].

AKAM, M .

CELL, 1989, 57 (03) :347-349

[3] CRANIOFACIAL ABNORMALITIES INDUCED BY ECTOPIC EXPRESSION OF THE HOMEOBOX GENE HOX-1.1 IN TRANSGENIC MICE [J].

BALLING, R ;

MUTTER, G ;

GRUSS, P ;

KESSEL, M .

CELL, 1989, 58 (02) :337-347

[4] HOX GENE ACTIVATION BY RETINOIC ACID [J].

BONCINELLI, E ;

SIMEONE, A ;

ACAMPORA, D ;

MAVILIO, F .

TRENDS IN GENETICS, 1991, 7 (10) :329-334

[5] DEVELOPMENTAL DEFECTS OF THE EAR, CRANIAL NERVES AND HINDBRAIN RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.6 [J].

CHISAKA, O ;

MUSCI, TS ;

CAPECCHI, MR .

NATURE, 1992, 355 (6360) :516-520

[6] REGIONALLY RESTRICTED DEVELOPMENTAL DEFECTS RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.5 [J].

CHISAKA, O ;

CAPECCHI, MR .

NATURE, 1991, 350 (6318) :473-479

[7]

CONLON R, 1992, P NATL ACAD SCI USA, V116, P357

[8] HOX-4 GENES AND THE MORPHOGENESIS OF MAMMALIAN GENITALIA [J].

DOLLE, P ;

IZPISUABELMONTE, JC ;

BROWN, JM ;

TICKLE, C ;

DUBOULE, D .

GENES & DEVELOPMENT, 1991, 5 (10) :1767-1776

[9] COORDINATE EXPRESSION OF THE MURINE HOX-5 COMPLEX HOMOEOBOX-CONTAINING GENES DURING LIMB PATTERN-FORMATION [J].

DOLLE, P ;

IZPISUABELMONTE, JC ;

FALKENSTEIN, H ;

RENUCCI, A ;

DUBOULE, D .

NATURE, 1989, 342 (6251) :767-772

[10]

DOLLE P, 1993, IN PRESS P NATL ACAD

← 1 2 3 4 5 →