MEMBRANE PARAMETERS, SIGNAL TRANSMISSION, AND THE DESIGN OF A GRADED POTENTIAL NEURON

被引:34
作者
VANHATEREN, JH [1 ]
LAUGHLIN, SB [1 ]
机构
[1] UNIV CAMBRIDGE, DEPT ZOOL, CAMBRIDGE CB2 3EJ, ENGLAND
来源
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY | 1990年 / 166卷 / 04期
关键词
Graded potential; Signal transmission; Vision;
D O I
10.1007/BF00192015
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The large monopolar cells (LMCs) of the fly, Calliphora vicina, visual system transmit graded potentials over distances of up to 1.0 mm. An electrical model was constructed to investigate the design principles relating their membrane parameters to signal transmission and filtering. Using existing anatomical measurements, a cable model (van Hateren 1986) was fitted to the measured intracellular responses of the cells to injected current. The LMC has three functional components: a distal synaptic zone of low impedance, an axon with high specific membrane resistance (>50·105 M Ω·μm2), and a high impedance proximal terminal. These components interact to transmit information efficiently. The low input impedance synaptic zone charges and discharges the axon rapidly, ensuring a good frequency response. The high resistance axon conducts signals with little decrement. The model shows that graded potential transmission in LMCs selectively filters synaptic noise and predicts the changes in response waveform that occur during transmission. The parameters of the model were adjusted to determine the relative costs and benefits of alternative cable designs. The design used in LMCs is the most expensive and the most effective. It requires the largest currents to generate responses but transmits signals with least decrement. Parallel neurons in the fly visual system have fewer input synapses and this could low-pass filter their graded response. © 1990, Springer-Verlag. All rights reserved.
引用
收藏
页码:437 / 448
页数:12
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