CYTOTOXICITIES OF SOME FLAVONOID ANALOGS

被引：66

作者：

CUSHMAN, M

NAGARATHNAM, D

机构：

[1] Department of Medianal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 06期

关键词：

D O I：

10.1021/np50078a027

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An array of 55 flavones having a variety of substituents was evaluated for cytotoxicity in five cancer cell cultures: A-549 lung carcinoma, MCF-7 breast carcinoma, HT-29 colon adenocarcinoma, SKMEL-5 melanoma, and MLM melanoma. Fifteen of the 55 flavone derivatives were significantly active against at least one of these cell cultures, and 4'-[(t-butyldimethylsilyl)oxy]-7,8-dihydroxy-3',5'-dimethoxyflavo[40] was the most active of all. Structure-activity relationships of these compounds are discussed.

引用

页码：1656 / 1660

页数：5

共 34 条

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