CYTOTOXICITIES OF SOME FLAVONOID ANALOGS

被引:66
作者
CUSHMAN, M
NAGARATHNAM, D
机构
[1] Department of Medianal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette
来源
JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 06期
关键词
D O I
10.1021/np50078a027
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
An array of 55 flavones having a variety of substituents was evaluated for cytotoxicity in five cancer cell cultures: A-549 lung carcinoma, MCF-7 breast carcinoma, HT-29 colon adenocarcinoma, SKMEL-5 melanoma, and MLM melanoma. Fifteen of the 55 flavone derivatives were significantly active against at least one of these cell cultures, and 4'-[(t-butyldimethylsilyl)oxy]-7,8-dihydroxy-3',5'-dimethoxyflavo[40] was the most active of all. Structure-activity relationships of these compounds are discussed.
引用
收藏
页码:1656 / 1660
页数:5
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