POSSIBLE INVOLVEMENT OF MU-2-MEDIATED MECHANISMS IN MU-MEDIATED ANTITUSSIVE ACTIVITY IN THE MOUSE

被引：22

作者：

KAMEI, J ^{[1
]}

IWAMOTO, Y ^{[1
]}

KAWASHIMA, N ^{[1
]}

SUZUKI, T ^{[1
]}

NAGASE, H ^{[1
]}

MISAWA, M ^{[1
]}

KASUYA, Y ^{[1
]}

机构：

[1] TORAY INDUSTRIES LTD,BASIC RES LABS,KAMAKURA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 149卷 / 02期

关键词：

ANTITUSSIVE EFFECT; COUGH; NALOXONAZINE; NALOXONE; ANTINOCICEPTION; MOUSE;

D O I：

10.1016/0304-3940(93)90763-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of pretreatment with naloxonazine on mu-opioid agonist-mediated antitussive effects was studied in mice. The antitussive effects of [D-Ala2, MePhe4, Gly-ol5]enkephalin (DAMGO) and morphine were significantly antagonized by naloxone pretreatment, 1 mg/kg given i.p. 5 min earlier, but not by naloxonazine pretreatment, 35 mg/kg given s.c. 24 h earlier. In contrast, the antinociceptive effects of these mu agonists, as determined by the tail-flick method, were significantly reduced by pretreatment with both naloxone and naloxonazine. These results suggest that mu2 rather than mu1 mechanisms are involved in mu-mediated antitussive effects.

引用

页码：169 / 172

页数：4

共 17 条

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