IMINOPHOSPHORANE-MEDIATED SYNTHESIS OF FUSED URACILS - A FACILE ONE-POT PREPARATION OF PYRIMIDO[4,5-D]PYRIMIDINE DERIVATIVES

被引：28

作者：

MOLINA, P

VILAPLANA, MJ

PEREZ, J

机构：

[1] Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Murcia, E-30071 Murcia, Campus de Espinardo

来源：

TETRAHEDRON | 1990年 / 46卷 / 23期

关键词：

D O I：

10.1016/S0040-4020(01)90083-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aza Wittig-type reaction of iminophosphoranes 3, 5-[(N-Arylimino)methyl]-6-[(triphenylphosphoranylidene)amino]-1, 3-dimethyl uracils, with aromatic isocyanates leads to the functionalized pyrimido[4,5-d]pyrimidines 4. Iminophosphoranes 5, prepared from 3 by selective reduction with sodium borohydride, undergo dihydropyrimido annelation by reaction with isocyanates to give 7-amino-6-aryl-1,3-dimethyl-1,2,3,4,5,6-hexahydropyrimido[4,5-d]pyrimidines 6. © 1990.

引用

页码：7855 / 7864

页数：10

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