THE EXTRAORDINARY ENZYMES INVOLVED IN ERYTHROMYCIN BIOSYNTHESIS

被引：47

作者：

STAUNTON, J

机构：

[1] University Chemical Laboratory, Cambridge, CBZ 1EW, Lensfield Road

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 10期

关键词：

D O I：

10.1002/anie.199113021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nature's secret of how highly complicated molecules like erythromycin A are synthesized is no longer completely safe. Lately good progress has been made towards understanding the synthesis of polyketides (to which erythromycin A belongs) by polyketide synthases (PKS). Fatty acids are synthesized along similar lines. However, erythromycin-PKS is a covalently bonded giant protein (cassette/module organization) that shows many enzyme activities. The molecule's skeleton is built up in several reaction cycles by this giant protein.

引用

页码：1302 / 1306

页数：5

共 14 条

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