INDUCTION OF THE PROTOONCOGENE C-JUN BY ANGIOTENSIN-II

被引：148

作者：

NAFTILAN, AJ ^{[1
]}

GILLILAND, GK ^{[1
]}

ELDRIDGE, CS ^{[1
]}

KRAFT, AS ^{[1
]}

机构：

[1] UNIV ALABAMA,DIV HEMATOL ONCOL,BIRMINGHAM,AL 35294

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 10期

关键词：

D O I：

10.1128/MCB.10.10.5536

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-jun and, in addition, could activate the AP-1 enhancer element. These data add support for a role of Ang II as an important mediator of vascular smooth muscle cell growth.

引用

页码：5536 / 5540

页数：5