AN ANALYSIS OF SOME BATCH AND CONTINUOUS KINETIC DATA OF SPECIFIC MONOCLONAL-ANTIBODY PRODUCTION FROM HYBRIDOMAS

被引：11

作者：

PHILLIPS, PJ

MARQUIS, CP

BARFORD, JP

HARBOUR, C

机构：

[1] Department of Chemical Engineering, University of Sydney, 2006, NSW

[2] Department of Infectious Diseases, University of Sydney, 2006, NSW

来源：

CYTOTECHNOLOGY | 1991年 / 6卷 / 03期

关键词：

D O I：

10.1007/BF00624757

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An analysis of batch and continuous kinetic data obtained from hybridoma cell cultures has been performed with particular reference to the existence of specific antibody production profiles. The results presented by several groups, including our own, have been studied. Our analysis suggests that different interpretations of the data can be made to those previously presented in the literature. In view of the significance of these profiles, particularly in terms of production strategies designed to maximise antibody production, we believe that more consideration needs to be given to accuracy in reporting of kinetic studies in the future.

引用

页码：189 / 195

页数：7