OMEGA-AGA TOXIN-IVA BLOCKS HIGH-VOLTAGE-ACTIVATED CALCIUM-CHANNEL CURRENTS IN CULTURED PARS-INTERCEREBRALIS NEUROSECRETORY-CELLS OF ADULT LOCUSTA-MIGRATORIA

被引：20

作者：

BICKMEYER, U ^{[1
]}

ROSSLER, W ^{[1
]}

WIEGAND, H ^{[1
]}

机构：

[1] UNIV MARBURG, FACHBEREICH BIOL ZOOL, AG NEUROBIOL, D-35032 MARBURG, GERMANY

来源：

NEUROSCIENCE LETTERS | 1994年 / 181卷 / 1-2期

关键词：

CALCIUM CHANNEL CURRENT; OMEGA AGA TOXIN IVA; MEDIAL NEUROSECRETORY CELL; LOCUST; CELL CULTURE; INSECT;

D O I：

10.1016/0304-3940(94)90572-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the whole cell patch-clamp technique, calcium (Ca) channel currents from cultured medial neurosecretory cells (MNSCs) of Locusta migratoria (Rossler and Bickmeyer, 1993) were investigated. The calcium channel blocker omega AGA toxin IVA (AGA IVA) blocks a fraction of these calcium channel currents in similar to 30% of MNSCs, without a shift in the I-V relationship. The block can be at least partially reversed by strong depolarizing voltage pulses as described for vertebrate neurones from Mintz et al. (1992). The existence of probably more than three calcium channel types in insects is discussed.

引用

页码：113 / 116

页数：4

共 23 条

[1] P-TYPE CA2+ CHANNELS MEDIATE EXCITATORY AND INHIBITORY SYNAPTIC TRANSMITTER RELEASE IN CRAYFISH MUSCLE [J].