DECREASED ACTIVITY OF RAT A10-DOPAMINE NEURONS FOLLOWING WITHDRAWAL FROM REPEATED COCAINE

被引：53

作者：

ACKERMAN, JM ^{[1
]}

WHITE, FJ ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,LAFAYETTE CLIN,NEUROPSYCHOPHARMACOL LAB,951 E LAFAYETTE,DETROIT,MI 48207

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 218卷 / 01期

关键词：

COCAINE; DOPAMINE NEURONS; WITHDRAWAL; VENTRAL TEGMENTAL AREA; ELECTROPHYSIOLOGY;

D O I：

10.1016/0014-2999(92)90161-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Electrophysiological techniques were used to determine the basal activity of A10 dopamine (DA) neurons in thc rat ventral tegmental area after a 10-14 day withdrawal from repeated cocaine treatment (10.0 mg/kg i.p. twice daily for 14 days). The number of spontaneously active A10 DA cells was significantly decreased (42%) in the cocaine-treated rats. This decreased activity may underlie the diminished basal levels of synaptic DA within the nucleus accumbens previously reported in cocaine-withdrawn rats and may account for anhedonia, anergia and cocaine craving reported by withdrawn cocaine addicts.

引用

页码：171 / 173

页数：3

共 10 条

[1] A10 SOMATODENDRITIC DOPAMINE AUTORECEPTOR SENSITIVITY FOLLOWING WITHDRAWAL FROM REPEATED COCAINE TREATMENT [J].