HLA-BW54-DR4-DRW53-DQW4 HAPLOTYPE CONTROLS NONRESPONSIVENESS TO HEPATITIS-B SURFACE-ANTIGEN VIA CD8-POSITIVE SUPPRESSOR T-CELLS

被引：49

作者：

WATANABE, H ^{[1
]}

OKUMURA, M ^{[1
]}

HIRAYAMA, K ^{[1
]}

SASAZUKI, T ^{[1
]}

机构：

[1] KYUSHU UNIV,MED INST BIOREGULAT,DEPT GENET,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

TISSUE ANTIGENS | 1990年 / 36卷 / 02期

关键词：

D O I：

10.1111/j.1399-0039.1990.tb01802.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Abstract: We have previously reported that in nonresponders to hepatitis‐B (HB) vaccine there was an HLA‐linked immune suppression gene for hepatitis‐B surface antigen (Is‐HBsAg) controlling the nonresponsiveness to HBsAg, through HBsAg‐specific suppressor T cells, and that the Is‐HBsAg was in strong linkage disequilibrium with the HLA‐Bw54‐DR4‐DRw53 haplotype (1). We have now done the HLA typing on an additional 6 nonresponders, and using the system of T‐cell proliferative response to HBsAg we found that the Is‐HBsAg controlled the nonresponsiveness to HBsAg through HBsAg‐specific suppressor T cells in nonresponders to HB vaccine who have HLA‐Bw54‐DR4‐DRw53‐DQw4 haplotype. T‐and B‐cell recognition of HB vaccines might play an important role at 3 to 5 weeks after the last immunization. Use of an anti‐HLA monoclonal antibody has shown that the HLA‐DR molecule plays an important role in helper T‐cell proliferation in nonresponders, although the role of HLA‐DQ molecule in nonresponders was unclear. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：69 / 74

页数：6

共 26 条

[1] GENETIC PREDICTION OF NONRESPONSE TO HEPATITIS-B VACCINE
ALPER, CA
KRUSKALL, MS
MARCUSBAGLEY, D
CRAVEN, DE
KATZ, AJ
BRINK, SJ
DIENSTAG, JL
AWDEH, Z
YUNIS, EJ
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (11) : 708 - 712
[2] BAAKMAN E, 1987, IMMUNOL TODAY, V8, P265
[3] CELIS E, 1988, J IMMUNOL, V140, P1808
[4] PRESENTATION OF AN IMMUNODOMINANT T-CELL EPITOPE OF HEPATITIS-B SURFACE-ANTIGEN BY THE HLA-DPW4 MOLECULE
CELIS, E
KARR, RW
[J]. JOURNAL OF VIROLOGY, 1989, 63 (02) : 747 - 752
[5] T-CELL ANTIGENIC SITES TEND TO BE AMPHIPATHIC STRUCTURES
DELISI, C
BERZOFSKY, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) : 7048 - 7052
[6] FILION LG, 1988, CLIN EXP IMMUNOL, V71, P405
[7] HEBERKATZ E, 1986, CURR TOP MICROBIOL, V130, P51
[8] MONOCLONAL-ANTIBODIES TO HLA-DP-TRANSFECTED MOUSE L-CELLS
HEYES, J
AUSTIN, P
BODMER, J
BODMER, W
MADRIGAL, A
MAZZILLI, MC
TROWSDALE, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (10) : 3417 - 3421
[9] ITOH Y, 1986, P NATL ACAD SCI USA, V83, P9714
[10] INFLUENZA VIRUS-SPECIFIC HUMAN CYTOTOXIC-T CELL CLONES - HETEROGENEITY IN ANTIGENIC SPECIFICITY AND RESTRICTION BY CLASS-II MHC PRODUCTS
KAPLAN, DR
GRIFFITH, R
BRACIALE, VL
BRACIALE, TJ
[J]. CELLULAR IMMUNOLOGY, 1984, 88 (01) : 193 - 206

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