TISSUE INHIBITOR OF METALLOPROTEINASES FROM HUMAN BONE-MARROW STROMAL CELL-LINE KM 102 HAS ERYTHROID-POTENTIATING ACTIVITY, SUGGESTING ITS POSSIBLY BIFUNCTIONAL ROLE IN THE HEMATOPOIETIC MICROENVIRONMENT

被引：54

作者：

HAYAKAWA, T ^{[1
]}

YAMASHITA, K ^{[1
]}

KISHI, J ^{[1
]}

HARIGAYA, K ^{[1
]}

机构：

[1] CHIBA UNIV,SCH MED,DEPT PATHOL,CHIBA 280,JAPAN

来源：

FEBS LETTERS | 1990年 / 268卷 / 01期

关键词：

Bone marrow stromal cell line (KM 102); Erythroid-potentiating activity (EPA); Tissue inhibitor of metalloproteinases (TIMP);

D O I：

10.1016/0014-5793(90)80989-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we demonstrated that tissue inhibitor of metalloproteinases (TIMP) produced by human bone marrow stromal cell line KM-102 had erythroid-potentiating activity (EPA) which stimulates the proliferation of erythroid progenitor cells. We, then, propose a scheme for the bifunctional role ofTIMP/EPA in hematopoietic microenvironment, that is, the maintenance of the integrity of bone marrow matrix and the proliferation of erythroid progenitor cells proceeding on the matrix. © 1990.

引用

页码：125 / 128

页数：4