GENETIC-ANALYSIS OF THE LINKAGE BETWEEN CHROMOSOME-11Q AND ATOPY

被引:58
作者
LYMPANY, P
WELSH, KI
COCHRANE, GM
KEMENY, DM
LEE, TH
机构
[1] UMDS, GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS, 4TH FLOOR,HUNTS HOUSE, LONDON SE1 9RT, ENGLAND
[2] CHURCHILL HOSP, CTR TISSUE TYPING TRANSPLANTAT, OXFORD OX3 7LJ, ENGLAND
[3] UMDS, GUYS HOSP, DEPT RESP MED, LONDON, ENGLAND
关键词
D O I
10.1111/j.1365-2222.1992.tb00134.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Previous work has suggested that there is a genetic predisposition for the development of both asthma and atopy. A recent study has also shown that there is a striking link between chromosome 11q and the IgE response underlying asthma and rhinitis. To further assess the linkage between chromosome 11q and atopy, we have studied nine families of two and, in many instances, three generations with the index case having asthma and/or atopy. Using two restriction fragment length polymorphism probes associated with the regions 11q12-q13.2, namely PYGM and INT2, we have been unable to confirm a significant link between this region of chromosome 11q and atopy as defined by a positive skin-prick test and/or a raised specific IgE and/or a raised total IgE.
引用
收藏
页码:1085 / 1092
页数:8
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