FAMILIAL MALE BREAST-CANCER IS NOT LINKED TO THE BRCA1 LOCUS ON CHROMOSOME 17Q

被引：119

作者：

STRATTON, MR

FORD, D

NEUHASEN, S

SEAL, S

WOOSTER, R

FRIEDMAN, LS

KING, MC

EGILSSON, V

DEVILEE, P

MCMANUS, R

DALY, PA

SMYTH, E

PONDER, BAJ

PETO, J

CANNONALBRIGHT, L

EASTON, DF

GOLDGAR, DE

机构：

[1] INST CANC RES, CRC, EPIDEMIOL SECT, SUTTON SM2 5NG, SURREY, ENGLAND

[2] UNIV UTAH, DEPT MED INFORMAT, SALT LAKE CITY, UT 84108 USA

[3] UNIV UTAH, DEPT INTERNAL MED, SALT LAKE CITY, UT 84108 USA

[4] UNIV CALIF BERKELEY, DEPT MOLEC & CELL BIOL, BERKELEY, CA 94720 USA

[5] UNIV CALIF BERKELEY, SCH PUBL HLTH, BERKELEY, CA 94720 USA

[6] UNIV HOSP ICELAND, CELL BIOL LAB, IS-121 REYKJAVIK, ICELAND

[7] LEIDEN STATE UNIV, DEPT PATHOL, 2333 AL LEIDEN, NETHERLANDS

[8] UNIV DUBLIN TRINITY COLL, ST JAMES HOSP, SCH MED, DEPT MED, DUBLIN 8, IRELAND

[9] WESTERN GEN HOSP, MRC, HUMAN GENET UNIT, EDINBURGH EH4 2XU, MIDLOTHIAN, SCOTLAND

[10] UNIV CAMBRIDGE, DEPT PATHOL, CRC, HUMAN CANC GENET GRP, CAMBRIDGE CB2 1QP, ENGLAND

来源：

NATURE GENETICS | 1994年 / 7卷 / 01期

关键词：

D O I：

10.1038/ng0594-103

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Breast cancer in men is about a hundredfold less common than in women and this has hindered research into its genetic basis. We have examined 22 families with at least one case of male breast cancer for linkage to the hereditary breast and ovarian cancer locus, BRCA1, on chromosome 17q. We found strong evidence against linkage to BRCA1 (led score - 16.63) and the best estimate of the proportion of linked families was 0% (95% Cl 0-18%). Our results indicate that there is a gene(s) other than BRCA1 which predisposes to early-onset breast cancer in women and which confers a higher risk of male breast cancer. Identification of additional pedigrees that include cases of male breast cancer may therefore facilitate the mapping and isolation of this gene.

引用

页码：103 / 107

页数：5

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