STRAINS OF MYCOBACTERIUM-TUBERCULOSIS DIFFER IN SUSCEPTIBILITY TO REACTIVE NITROGEN INTERMEDIATES IN-VITRO

被引：77

作者：

OBRIEN, L

CARMICHAEL, J

LOWRIE, DB

ANDREW, PW

机构：

[1] UNIV LEICESTER,DEPT MICROBIOL & IMMUNOL,LEICESTER LE1 9HN,LEICS,ENGLAND

[2] NATL INST MED RES,LEPROSY & MYCOBACTERIAL DIS LABS,LONDON,ENGLAND

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 11期

关键词：

D O I：

10.1128/IAI.62.11.5187-5190.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects on the viability of Mycobacterium tuberculosis strains and one Mycobacterium bovis strain from exposure to sodium nitrite for 24 h, in both neutral and acidic media, were tested. The in vitro resistance of mycobacteria to reactive nitrogen intermediates, generated at an acidic pH, was found to have a significant (P < 0.05) positive correlation to the virulence of strains in guinea pigs.

引用

页码：5187 / 5190

页数：4

共 27 条

[11] GOREN MB, 1982, BRIT J EXP PATHOL, V63, P693
[12] SPECIFIC AMINO-ACID (L-ARGININE) REQUIREMENT FOR THE MICROBIOSTATIC ACTIVITY OF MURINE MACROPHAGES
GRANGER, DL
HIBBS, JB
PERFECT, JR
DURACK, DT
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (04) : 1129 - 1136
[13] NEUTRALIZATION OF GAMMA INTERFERON AND TUMOR-NECROSIS-FACTOR-ALPHA BLOCKS INVIVO SYNTHESIS OF NITROGEN-OXIDES FROM L-ARGININE AND PROTECTION AGAINST FRANCISELLA-TULARENSIS INFECTION IN MYCOBACTERIUM-BOVIS BCG-TREATED MICE
GREEN, SJ
NACY, CA
SCHREIBER, RD
GRANGER, DL
CRAWFORD, RM
MELTZER, MS
FORTIER, AH
[J]. INFECTION AND IMMUNITY, 1993, 61 (02) : 689 - 698
[14] GREEN SJ, 1990, J IMMUNOL, V144, P278
[15] VIRULENCE AND RESISTANCE TO SUPEROXIDE, LOW PH AND HYDROGEN-PEROXIDE AMONG STRAINS OF MYCOBACTERIUM-TUBERCULOSIS
JACKETT, PS
ABER, VR
LOWRIE, DB
[J]. JOURNAL OF GENERAL MICROBIOLOGY, 1978, 104 (JAN): : 37 - 45
[16] JAMES SL, 1989, J IMMUNOL, V143, P4208
[17] MITCHISON D A, 1960, Tubercle, V41, P1, DOI 10.1016/S0041-3879(60)80019-0
[18] THE L-ARGININE - NITRIC-OXIDE PATHWAY
MONCADA, S
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1992, 145 (03): : 201 - 227
[19] REACTION OF NITRIC-OXIDE WITH HYDROGEN-PEROXIDE TO PRODUCE POTENTIALLY CYTOTOXIC SINGLET OXYGEN AS A MODEL FOR NITRIC OXIDE-MEDIATED KILLING
NORONHADUTRA, AA
EPPERLEIN, MM
WOOLF, N
[J]. FEBS LETTERS, 1993, 321 (01) : 59 - 62
[20] GUINEA-PIG ALVEOLAR MACROPHAGE KILLING OF MYCOBACTERIUM-TUBERCULOSIS, INVITRO, DOES NOT REQUIRE HYDROGEN-PEROXIDE OR HYDROXYL RADICAL
OBRIEN, S
ANDREW, PW
[J]. MICROBIAL PATHOGENESIS, 1991, 11 (04) : 229 - 236

← 1 2 3 →