GAMMA-GLUTAMYL-TRANSFERASE EXPRESSION DURING ALL-TRANS-RETINOIC ACID-INDUCED DIFFERENTIATION OF HEMATOPOIETIC-CELL LINES

被引：10

作者：

ELYAAGOUBI, M ^{[1
]}

HACHAD, H ^{[1
]}

LEH, H ^{[1
]}

SIEST, G ^{[1
]}

WELLMAN, M ^{[1
]}

机构：

[1] CTR MED,CNRS,URA 597,F-54000 NANCY,FRANCE

来源：

FEBS LETTERS | 1995年 / 369卷 / 2-3期

关键词：

DIFFERENTIATION; GAMMA-GLUTAMYL-TRANSFERASE; HEMATOPOIETIC CELL LINE; RETINOIC ACID; RETINOID;

D O I：

10.1016/0014-5793(95)00753-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gamma-glutamyltransferase activity, genes transcripts and differentiation by all-trans retinoic acid have been investigated in cultured HL-60, U937 and K562 cells. Acquisition of morphological and functional characteristics confirmed the terminal differentiation of HL-60 and U937 cells. All-trans retinoic acid increased gamma-glutamyltransferase activity in a cell type- and time-dependent manner. Treatments with all-trans retinoic acid isomers and structurally analogs showed that only retinoids with carboxylic acid group mere able to induce enzyme activity in terminal differentiated cells. Additionally, the analysis of gamma-glutamyltransferase genes transcription products demonstrated dearly that, both in untreated and in RA treated cells, only mRNA type I transcribed from the gene 6, was expressed.

引用

页码：183 / 186

页数：4

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