STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT DOES NOT INFLUENCE GLUCOSE-UTILIZATION OF THE CEREBRAL-CORTEX IN ANESTHETIZED RATS

被引：35

作者：

KIMURA, A ^{[1
]}

SATO, A ^{[1
]}

TAKANO, Y ^{[1
]}

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT PHYSIOL,35-2 SAKAECHO,ITABASHI KU,TOKYO 173,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 119卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

Cortical cerebral blood flow; Glucose utilization; Nucleus basalis of Meynert; Rat; [!sup]14[!/sup]C]2-Deoxy-d-glucose;

D O I：

10.1016/0304-3940(90)90766-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of focal electrical stimulation of the nucleus basalis of Meynert (NBM) on the regional cerebral metabolic rate for glucose (rCMRglc) was examined in halothane-anesthetized rats using the quantitative [14C]2-deoxy-d-glucose method. The stimulation of the unilateral NBM (with parameters of 200 μA, 0.5 ms, 50 Hz for 45 min) did not influence rCMRglc in any brain regions except for the stimulated NBM itself. In cerebral cortex ipsilateral to the NBM stimulated, the regional cerebral blood flow (rCBF) was increased by the NBM stimulation through the stimulated period, while rCMRglc was not increased. These results suggest that the increase in rCBF in the cortex following focal electrical stimulation of the NBM is not a consequence of an increase in rCMRglc in the cerebral cortex. © 1990.

引用

页码：101 / 104

页数：4

共 15 条

[1] RESPONSES OF REGIONAL CEREBRAL BLOOD-FLOW FOLLOWING FOCAL ELECTRICAL-STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT AND THE MEDIAL SEPTUM USING THE [C-14] IODOANTIPYRINE METHOD IN RATS [J].

ADACHI, T ;

INANAMI, O ;

OHNO, K ;

SATO, A .

NEUROSCIENCE LETTERS, 1990, 112 (2-3) :263-268

[2] STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT AND SUBSTANTIA INNOMINATA PRODUCES WIDESPREAD INCREASES IN CEREBRAL BLOOD-FLOW IN THE FRONTAL, PARIETAL AND OCCIPITAL CORTICES [J].

ADACHI, T ;

BIESOLD, D ;

INANAMI, O ;

SATO, A .

BRAIN RESEARCH, 1990, 514 (01) :163-166

[3] STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT INCREASES CEREBRAL CORTICAL BLOOD-FLOW IN RATS [J].

BIESOLD, D ;

INANAMI, O ;

SATO, A ;

SATO, Y .

NEUROSCIENCE LETTERS, 1989, 98 (01) :39-44

[4] FOCAL PHYSIOLOGICAL UNCOUPLING OF CEREBRAL BLOOD-FLOW AND OXIDATIVE-METABOLISM DURING SOMATOSENSORY STIMULATION IN HUMAN-SUBJECTS [J].

FOX, PT ;

RAICHLE, ME .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (04) :1140-1144

[5] EFFECT OF STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT ON BLOOD-FLOW AND EXTRACELLULAR LACTATE IN THE CEREBRAL-CORTEX WITH SPECIAL REFERENCE TO THE EFFECT OF NOXIOUS-STIMULATION OF SKIN AND HYPOXIA [J].

HALLSTROM, A ;

SATO, A ;

SATO, Y ;

UNGERSTEDT, U .

NEUROSCIENCE LETTERS, 1990, 116 (1-2) :227-232

[6] EXTRACELLULAR LACTIC-ACID AS AN INDICATOR OF BRAIN METABOLISM - CONTINUOUS ONLINE MEASUREMENT IN CONSCIOUS, FREELY MOVING RATS WITH INTRASTRIATAL DIALYSIS [J].

KUHR, WG ;

KORF, J .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (01) :130-137

[7] STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT INCREASES ACETYLCHOLINE-RELEASE IN THE CEREBRAL-CORTEX IN RATS [J].

KUROSAWA, M ;

SATO, A ;

SATO, Y .

NEUROSCIENCE LETTERS, 1989, 98 (01) :45-50

[8] DECREASED CORTICAL GLUCOSE-UTILIZATION AFTER IBOTENATE LESION OF THE RAT VENTROMEDIAL GLOBUS PALLIDUS [J].

LONDON, ED ;

MCKINNEY, M ;

DAM, M ;

ELLIS, A ;

COYLE, JT .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1984, 4 (03) :381-390

[9] CORTICAL PROJECTION PATTERNS OF MAGNOCELLULAR BASAL NUCLEUS SUBDIVISIONS AS REVEALED BY ANTEROGRADELY TRANSPORTED PHASEOLUS-VULGARIS LEUKOAGGLUTININ [J].

LUITEN, PGM ;

GAYKEMA, RPA ;

TRABER, J ;

SPENCER, DG .

BRAIN RESEARCH, 1987, 413 (02) :229-250

[10] ELECTRICAL-STIMULATION OF CEREBELLAR FASTIGIAL NUCLEUS INCREASES CEREBRAL CORTICAL BLOOD-FLOW WITHOUT CHANGE IN LOCAL METABOLISM - EVIDENCE FOR AN INTRINSIC SYSTEM IN BRAIN FOR PRIMARY VASODILATION [J].

NAKAI, M ;

IADECOLA, C ;

RUGGIERO, DA ;

TUCKER, LW ;

REIS, DJ .

BRAIN RESEARCH, 1983, 260 (01) :35-49

← 1 2 →