PREVALENCE OF ACUTE DYSTONIC REACTIONS ASSOCIATED WITH NEUROLEPTIC TREATMENT WITH AND WITHOUT ANTICHOLINERGIC PROPHYLAXIS

被引：18

作者：

SPINA, E

STURIALE, V

VALVO, S

ANCIONE, M

DIROSA, AE

MEDURI, M

CAPUTI, AP

机构：

[1] CTR MENTAL HLTH,USL 41,MESSINA,ITALY

[2] CTR MENTAL HLTH,USL 23,RAGUSA,ITALY

[3] UNIV MESSINA,INST MENTAL HLTH,I-98100 MESSINA,ITALY

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1993年 / 8卷 / 01期

关键词：

ACUTE DYSTONIC REACTIONS; ANTICHOLINERGIC PROPHYLAXIS; BUTHYROPHENONES; NEUROLEPTICS; PHENOTHIAZINES; PREVALENCE; SUBSTITUTED BENZAMIDES;

D O I：

10.1097/00004850-199300810-00003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The occurrence of acute dystonic reactions was intensively monitored in a population of 646 patients, 379 males and 267 females, aged 18-87 years, consecutively admitted to different psychiatric units and treated with neuroleptics alone or in combination with anticholinergic drugs. Thirty-four patients experienced acute dystonic reactions yielding a total incidence of 5.3%. There was a tendency towards a higher frequency of dystonia in males than in females, and in young patients than in older ones. Patients without anticholinergic medication had a higher frequency of the reaction than those receiving anticholinergic drugs (8.5% vs. 2.8%; p < 0.02). Neuroleptic-induced dystonia was more common in patients treated with buthyrophenones than in those receiving phenothiazines or substituted benzamides.

引用

页码：21 / 24

页数：4