STEREOSELECTIVE FORMATION OF TRICYCLIC CEPHALOSPORINS IN REACTIONS OF CEPHEM PHOSPHORUS YLIDES AND KETOALDEHYDES

被引：6

作者：

PITLIK, J ^{[1
]}

GUNDA, TE ^{[1
]}

BATTA, G ^{[1
]}

JEKO, J ^{[1
]}

机构：

[1] ALKALOIDA CHEM CO LTD,H-4440 TISZAVASVARI,HUNGARY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80976-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel tricyclic cephalosporins (3a-d) and cephem 3-alpha,beta-unsaturated ketones (2c-f) were obtained in a Wittig-type approach with cephalosporin C-3 phosphorus ylides and keto-substituted aldehydes in completely stereoselective reactions. The product ratio was found to be a function of the substituent on the aldehyde. Structure elucidation of the products was carried out by means of NMR methods and molecular mechanics.

引用

页码：2451 / 2456

页数：6

共 12 条

[1]

BUNCAL E, 1975, CARBANIONS MECHANIST, P59

[2] PALLADIUM CATALYSIS IN CEPHALOSPORIN CHEMISTRY - GENERAL METHODOLOGY FOR THE SYNTHESIS OF CEPHEM SIDE-CHAINS [J].