G-PROTEINS (GI, GO) IN THE BASAL GANGLIA OF CONTROL AND SCHIZOPHRENIC BRAIN

被引：36

作者：

OKADA, F ^{[1
]}

CROW, TJ ^{[1
]}

ROBERTS, GW ^{[1
]}

机构：

[1] CLIN RES CTR,DIV PSYCHIAT,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1990年 / 79卷 / 03期

关键词：

guanosine triphosphate (GTP)-binding protein; isletactivating protein (pertussis toxin); Schizophrenia; striatum;

D O I：

10.1007/BF01245133

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain. © 1990 Springer-Verlag.

引用

页码：227 / 234

页数：8

共 34 条

[1] CHROMOSOMAL LOCALIZATION OF GENES ENCODING GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNITS IN MOUSE AND HUMAN
BLATT, C
EVERSOLECIRE, P
COHN, VH
ZOLLMAN, S
FOURNIER, REK
MOHANDAS, LT
NESBITT, M
LUGO, T
JONES, DT
REED, RR
WEINER, LP
SPARKES, RS
SIMON, MI
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) : 7642 - 7646
[2] ANTISERUM RAISED AGAINST RESIDUES 159-168 OF THE GUANINE NUCLEOTIDE-BINDING PROTEIN GI3-ALPHA REACTS WITH EPENDYMAL CELLS AND SOME NEURONS IN THE RAT-BRAIN CONTAINING CHOLECYSTOKININ-LIKE OR CHOLECYSTOKININ-LIKE AND TYROSINE 3-HYDROXYLASE-LIKE IMMUNOREACTIVITIES
CORTES, R
HOKFELT, T
SCHALLING, M
GOLDSTEIN, M
GOLDSMITH, P
SPIEGEL, A
UNSON, C
WALSH, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) : 9351 - 9355
[3] FLUPENTHIXOL-H-3 BINDING IN POSTMORTEM BRAINS OF SCHIZOPHRENICS - EVIDENCE FOR A SELECTIVE INCREASE IN DOPAMINE-D2 RECEPTORS
CROSS, AJ
CROW, TJ
OWEN, F
[J]. PSYCHOPHARMACOLOGY, 1981, 74 (02) : 122 - 124
[4] THE DOPAMINE HYPOTHESIS SURVIVES, BUT THERE MUST BE A WAY AHEAD
CROW, TJ
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1987, 151 : 460 - 465
[5] DeArmond SJ, 1976, PHOTOGRAPHIC ATLAS S, V2nd, DOI [10.1212/WNL.11.10.852, DOI 10.1212/WNL.11.10.852]
[6] DIAGNOSTIC CRITERIA FOR USE IN PSYCHIATRIC RESEARCH
FEIGHNER, JP
WOODRUFF, RA
WINOKUR, G
MUNOZ, R
ROBINS, E
GUZE, SB
[J]. ARCHIVES OF GENERAL PSYCHIATRY, 1972, 26 (01) : 57 - &
[7] INCREASE OF THE 40,000-MOL WT PERTUSSIS TOXIN SUBSTRATE (G-PROTEIN) IN THE FAILING HUMAN-HEART
FELDMAN, AM
CATES, AE
VEAZEY, WB
HERSHBERGER, RE
BRISTOW, MR
BAUGHMAN, KL
BAUMGARTNER, WA
VANDOP, C
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (01) : 189 - 197
[8] G-PROTEINS AND DUAL CONTROL OF ADENYLATE-CYCLASE
GILMAN, AG
[J]. CELL, 1984, 36 (03) : 577 - 579
[9] GUANINE NUCLEOTIDE-BINDING REGULATORY PROTEINS - MEDIATORS OF TRANSMEMBRANE SIGNALING
GRAZIANO, MP
GILMAN, AG
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1987, 8 (12) : 478 - 481
[10] IYENGAR R, 1987, J BIOL CHEM, V262, P9239

← 1 2 3 4 →