G-PROTEINS (GI, GO) IN THE BASAL GANGLIA OF CONTROL AND SCHIZOPHRENIC BRAIN

被引：36

作者：

OKADA, F ^{[1
]}

CROW, TJ ^{[1
]}

ROBERTS, GW ^{[1
]}

机构：

[1] CLIN RES CTR,DIV PSYCHIAT,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1990年 / 79卷 / 03期

关键词：

guanosine triphosphate (GTP)-binding protein; isletactivating protein (pertussis toxin); Schizophrenia; striatum;

D O I：

10.1007/BF01245133

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain. © 1990 Springer-Verlag.

引用

页码：227 / 234

页数：8

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