VISUAL ANOMALIES ASSOCIATED WITH ALBINISM

被引：67

作者：

CREEL, DJ

SUMMERS, CG

KING, RA

机构：

[1] V.A. Medical Center, Salt Lake City, Utah

[2] Department of Ophthalmology, University of Utah School of Medicine, Minneapolis, MN

[3] Department of Ophthalmology, University of Minnesota, Minneapolis, MN

[4] Department of Medicine, University of Minnesota, Minneapolis, MN

来源：

OPHTHALMIC PAEDIATRICS AND GENETICS | 1990年 / 11卷 / 03期

关键词：

Albinism; Evoked potentials; Melanin; Vision;

D O I：

10.3109/13816819009020979

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

All mammals with hypopigmentation of the retinal pigment epithelium have abnormal visual systems. Albino mammals have been found to have: (1) reduced numbers of uncrossed optic fibers projecting to all visual centers, (2) disorganization of the pattern (lamination) of the dorsal lateral geniculate nuclei, and (3) disorganization of projections from the dorsal lateral genic ulate nuclei to the visual cortex. The disorganization of central visual centers has catastrophic effects on stereovision and optokinetic nystagmus. Variable expression in oculocutaneous albinism suggests that affected individuals cannot always be identified by hypopigmentation, reduced visual acuity and nystagmus. Careful observation of foveal development in individuals even with normal vision is necessary to detect all persons with albinism. The scalp-recorded visually evoked potential designed to detect optic misrouting is the most reliable concomitant for determining albinism. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：193 / 200

页数：8

共 49 条

[11]

Creel D.J., Differences of ipsilateral and contralateral visually evoked responses in cats: strains compared, J Comp Physiol Psychol, 77, pp. 161-165, (1971)

[12]

Creel D., Giolli R.A., Retinogeniculate projections in albino and ocularly hypopigmented rats, J Comp Neurol, 166, 4, pp. 445-456, (1976)

[13]

Creel D., Hendrickson A.E., Leventhal A.G., Retinal projections in tyrosinase-negative albino cats, J Neurosci, 2, pp. 907-911, (1982)

[14]

Drager U.C., Olsen J.F., Origins of crossed and uncrossed retinal projections in pigmented and albino mice, J Comp Neurol, 191, pp. 383-412, (1980)

[15]

Guillery R.W., Hickey T.L., Kaas J.H., Felleman D.J., Debruyn E.J., Sparks D.L., Abnormal central visual pathways in the brain of an albino green monkey (Cercopilhecus aethiops), J Comp Neurol, 226, pp. 165-183, (1984)

[16]

Guillery R.W., Jeffery G., Cattanach B.M., Abnormally high variability in the uncrossed retinofugal pathway of mice with albino mosaicism, Development, 101, pp. 857-867, (1987)

[17]

Guillery R.W., Okoro A.N., Witkop C.J., Abnormal visual pathways in the brain of a human albino, Brain Res, 96, pp. 373-377, (1975)

[18]

Lavail J.H., Nixon R.A., Sidman R.L., Genetic control of retinal ganglion cell projections, J Comp Neurol, 182, pp. 399-422, (1978)

[19]

Sanderson K.J., Guillery R.W., Shackelford R.M., Congenitally abnormal visual pathways in mink (Mustela vision) with reduced retinal pigment, J Comp Neurol, 154, pp. 225-248, (1974)

[20]

Shatz C., A comparison of visual pathways in Boston and midwestern Siamese cats, J Comp Neurol, 171, pp. 225-228, (1977)

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