STEREOSELECTIVE CONSTRUCTION OF MOLECULES WITH A TRIFLUOROMETHYL GROUP

Since fluorine-containing molecules have been recently disclosed their high ability as pharmaceutically active compounds and optical devices, development of new methods are strongly required for the construction of especially, trifluoromethylated molecules in a highly diastereoselective manner. In this article, with pointing out special problems in the field of fluorine chemistry and explaining the reason why the authors reached to the idea to employ building blocks as one of the promising solution to the above problem, our recent results for the stereoselective preparation of chiral materials via organic, enzymatic, and catalytic antibody methodologies, respectively, are discussed in detail.