GENETIC-LINKAGE ANALYSIS OF THE MURINE DEVELOPMENTAL MUTANT VELVET COAT (VE) AND THE DISTAL CHROMOSOME 15 DEVELOPMENTAL GENES HOX-3.1, RAR-G, WNT-1, AND KRT-2

被引：8

作者：

HART, CP

COMPTON, JG

LANGLEY, SH

HUNIHAN, L

LECLAIR, KP

ZELENT, A

RODERICK, TH

RUDDLE, FH

机构：

[1] FAC MED STRASBOURG, INST CHIM BIOL,CNRS,GENET MOLEC EUCARYOTES LAB, INSERM, F-67085 STRASBOURG, FRANCE

[2] JACKSON LABS, BAR HARBOR, ME 04609 USA

来源：

JOURNAL OF EXPERIMENTAL ZOOLOGY | 1992年 / 263卷 / 01期

关键词：

D O I：

10.1002/jez.1402630109

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

We have identified restriction fragment length polymorphisms between Mus musculus and Mus spretus for the Chromosome 15 loci Hox-3, Wnt-1, Krt-2, Rar-g, and Ly-6. We followed the inheritance of these alleles in interspecific genetic test crosses between velvet coat (Ve) heterozygotes and M. spretus. The results suggest a gene order and recombination distances (in cM) of Ly-6-22-Wnt-1-2-Ve/Krt-2/Rar-g-3-Hox-3. No recombination was found between Ve, Krt-2, and Rar-g. The data also provide evidence for the hypothesis of a large-scale genomic duplication involving homologous gene pairs on mouse Chromosomes 15 and 11.

引用

页码：83 / 95

页数：13

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