ANTIOXIDANT ACTIVITY OF UBIQUINONE-3 IN HUMAN LOW-DENSITY-LIPOPROTEIN

The ability of ubiquinone-3, a short chain ubiquinone homologue, to prevent Cu2+ induced oxidation of human low density lipoprotein was investigated. The results are as follows: in the presence of ubiquinone-3 the extent of peroxidation, as determined by the formation of thiobarbituric acid reactive substances, was only one third of that found in its absence; the quinone can also prevent the fragmentation of apolipo-protein B-100 and the increase of the net negative surface charge of the particle. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.