TRYPANOSOMATIDAE CODON USAGE AND GC DISTRIBUTION

被引:19
作者
ALONSO, G
GUEVARA, P
RAMIREZ, JL
机构
[1] Centro de Biología Celular, Universidad Central de Venezuela, Caracas
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1992年 / 87卷 / 04期
关键词
TRYPANOSOMATIDAE; CODON USAGE; MUTATIONAL PRESSURE; GC CONTENT;
D O I
10.1590/S0074-02761992000400009
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
A study of Trypanosomatidae GC distribution and codon usage is presented. The codon usage patterns in coincidence with the phylogenetical data are similar in Crithidia and Leishmania, whereas they are more divergent in Trypanosoma brucei and T. cruzi. The analysis of the GC mutational pressure in these organisms reveals that T. brucei, and to a lesser extent T. cruzi, have evolved towards a more balanced use of all bases, whereas Leishmania and Crithidia retain features of a primeval genetic apparatus. Tables with the approximated GC mutational pressure in homologous genes, and codon usage in Trypanosomatidae are presented.
引用
收藏
页码:517 / 523
页数:7
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