TRANSIENT REDUCTION OF AUTOANTIBODIES AGAINST OXIDIZED LDL IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION

被引：49

作者：

SCHUMACHER, M ^{[1
]}

EBER, B ^{[1
]}

TATZBER, F ^{[1
]}

KAUFMANN, P ^{[1
]}

HALWACHS, G ^{[1
]}

FRUHWALD, FM ^{[1
]}

ZWEIKER, R ^{[1
]}

ESTERBAUER, H ^{[1
]}

KLEIN, W ^{[1
]}

机构：

[1] GRAZ UNIV,INST BIOCHEM,A-8036 GRAZ,AUSTRIA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1995年 / 18卷 / 06期

关键词：

OXIDIZED LDL AUTOANTIBODIES; ACUTE MYOCARDIAL INFARCTION; FREE RADICALS;

D O I：

10.1016/0891-5849(94)00216-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fifteen consecutive patients (mean age 66 +/- 14, range 31-82) with an acute myocardial infarction (MI) suitable for thrombolytic therapy were included in this study. Autoantibodies against oxidized low-density lipoprotein (LDL) were determined by enzyme-linked immunosorbent assay (ELISA). Patients (n = 10) with marked elevation of the MB isoenzyme of creatinine kinase (CK-MB)-mass had significant decreases of oLDL-Ab during the acute phase, with a minimum after 8 h following the onset of thrombolytic therapy (within-group significance: p < .001; between groups: p = .01). Patients (n = 5) with CK-MB-mass values less than 70 ng/ml did not show this phenomenon. Furthermore, significant correlations existed between CK-MB-mass and oLDL-Ab after 6 and 8 h (n = 15; r = .72; p = .003) and the time of the highest CK-MB-mass values (after 12 h) and the time of the maximal decrease of oLDL-Ab (after 8 h) (r = .74; p = .003). Our observations provide further evidence for the release of free radicals and for increased lipid peroxidation during reperfusion after prolonged ischemia. The decrease of oLDL-Ab appears to be a marker for the severity of MI.

引用

页码：1087 / 1091

页数：5

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