RATIONAL IMMUNOTHERAPY WITH INTERLEUKIN-2

被引：40

作者：

KAPLAN, G ^{[1
]}

COHN, ZA ^{[1
]}

SMITH, KA ^{[1
]}

机构：

[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT MED,HANOVER,NH 03756

来源：

BIO-TECHNOLOGY | 1992年 / 10卷 / 02期

关键词：

D O I：

10.1038/nbt0292-157

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interleukin 2 (IL-2), a T lymphocyte product released upon antigen stimulation, has been used for cancer therapy in high doses for more than five years. More recently, its potential as a stimulant of cell-mediated immunitY in infectious diseases, particularly those caused by intracellular microbes, has become appreciated. Drawing on the extensive information available as to the structure, cellular and molecular effects of IL-2, this review focuses on its use in patients with lepromatous leprosy and AIDS in low, physiologic doses. The data indicate that IL-2 is effective in stimulating cell-mediated immunity without systemic toxicity.

引用

页码：157 / 162

页数：6

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