Procalcitonin: A Key Marker in Children with Urinary Tract Infection

被引:18
作者
Leroy, Sandrine [1 ,2 ]
Gervaix, Alain [3 ]
机构
[1] Univ Oxford, Wolfson Coll Annexe, Ctr Stat Med, Linton Rd, Oxford OX2 6UD, England
[2] Pasteur Inst, F-75015 Paris, France
[3] Univ Hosp Geneva, Dept Pediat, CH-1211 Geneva, Switzerland
关键词
D O I
10.1155/2011/397618
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Urinary tract infections (UTIs) are the most common source of bacterial infections among young febrile children. Accurate diagnosis of acute pyelonephritis (APN) and vesicoureteral reflux (VUR) is important because of their association with renal scarring, leading in the cases to long-termcomplications. However, the gold standard examinations for both are either DMSA scan (for APN and scar) or cystography (for VUR) and present limitations (feasibility, pain, cost, etc.). Procalcitonin, a reliable marker of bacterial infections, was demonstrated to be a good predictor of both renal parenchymal involvement in the acute phase and late renal scars. Furthermore, it was also found to be associated with high-grade VUR and was the key tool of a clinical decision rule to predict high-grade VUR in children with a first UTI. Therefore, procalcitonin may certainly be found playing a role in the complex and still debated picture of which examination should be performed after UTI in children.
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页数:7
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