SPECIFIC INHIBITORS OF HERPES-SIMPLEX VIRUS THYMIDINE KINASE DIMINISH REACTIVATION OF LATENT VIRUS FROM EXPLANTED MURINE GANGLIA

被引：30

作者：

LEIB, DA

RUFFNER, KL

HILDEBRAND, C

SCHAFFER, PA

WRIGHT, GE

COEN, DM

机构：

[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,TUMOR VIRUS GENET LAB,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115

[4] UNIV MASSACHUSETTS,SCH MED,DEPT PHARMACOL,WORCESTER,MA 01655

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 06期

关键词：

D O I：

10.1128/AAC.34.6.1285

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the frequency of reactivation compared with that of untreated controls.

引用

收藏

页码：1285 / 1286

页数：2

相关论文

共 19 条

[1] THYMIDINE KINASE-NEGATIVE HERPES-SIMPLEX VIRUS MUTANTS ESTABLISH LATENCY IN MOUSE TRIGEMINAL GANGLIA BUT DO NOT REACTIVATE [J].

COEN, DM ;

KOSZVNENCHAK, M ;

JACOBSON, JG ;

LEIB, DA ;

BOGARD, CL ;

SCHAFFER, PA ;

TYLER, KL ;

KNIPE, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4736-4740

[2] LOW-LEVELS OF HERPES-SIMPLEX VIRUS THYMIDINE THYMIDYLATE KINASE ARE NOT LIMITING FOR SENSITIVITY TO CERTAIN ANTIVIRAL DRUGS OR FOR LATENCY IN A MOUSE MODEL [J].

COEN, DM ;

IRMIERE, AF ;

JACOBSON, JG ;

KERNS, KM .

VIROLOGY, 1989, 168 (02) :221-231

[3] MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY [J].

DUBBS, DR ;

KIT, S .

VIROLOGY, 1964, 22 (04) :493-&

[4]

ESTATHIOU S, 1989, J GEN VIROL, V70, P869

[5] PATHOGENICITY OF THYMIDINE KINASE-DEFICIENT MUTANTS OF HERPES-SIMPLEX VIRUS IN MICE [J].

FIELD, HJ ;

WILDY, P .

JOURNAL OF HYGIENE, 1978, 81 (02) :267-277

[6] N-2 PHENYLDEOXYGUANOSINE - A NOVEL SELECTIVE INHIBITOR OF HERPES-SIMPLEX THYMIDINE KINASE [J].

FOCHER, F ;

HILDEBRAND, C ;

FREESE, S ;

CIARROCCHI, G ;

NOONAN, T ;

SANGALLI, S ;

BROWN, N ;

SPADARI, S ;

WRIGHT, G .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (08) :1496-1500

[7] STRUCTURE-ACTIVITY-RELATIONSHIPS OF N-2-SUBSTITUTED GUANINES AS INHIBITORS OF HSV1 AND HSV2 THYMIDINE KINASES [J].

HILDEBRAND, C ;

SANDOLI, D ;

FOCHER, F ;

GAMBINO, J ;

CIARROCCHI, G ;

SPADARI, S ;

WRIGHT, G .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :203-206

[8] A HERPES-SIMPLEX VIRUS RIBONUCLEOTIDE REDUCTASE DELETION MUTANT IS DEFECTIVE FOR PRODUCTIVE ACUTE AND REACTIVATABLE LATENT INFECTIONS OF MICE AND FOR REPLICATION IN MOUSE CELLS [J].

JACOBSON, JG ;

LEIB, DA ;

GOLDSTEIN, DJ ;

BOGARD, CL ;

SCHAFFER, PA ;

WELLER, SK ;

COEN, DM .

VIROLOGY, 1989, 173 (01) :276-283

[9] INDUCTION OF BOTH THYMIDINE AND DEOXYCYTIDINE KINASE-ACTIVITY BY HERPES VIRUSES [J].

JAMIESON, AT ;

GENTRY, GA ;

SUBAKSHA.JH .

JOURNAL OF GENERAL VIROLOGY, 1974, 24 (SEP) :465-480

[10] IMMEDIATE-EARLY REGULATORY GENE MUTANTS DEFINE DIFFERENT STAGES IN THE ESTABLISHMENT AND REACTIVATION OF HERPES-SIMPLEX VIRUS LATENCY [J].

LEIB, DA ;

COEN, DM ;

BOGARD, CL ;

HICKS, KA ;

YAGER, DR ;

KNIPE, DM ;

TYLER, KL ;

SCHAFFER, PA .

JOURNAL OF VIROLOGY, 1989, 63 (02) :759-768