SPECIFIC INHIBITORS OF HERPES-SIMPLEX VIRUS THYMIDINE KINASE DIMINISH REACTIVATION OF LATENT VIRUS FROM EXPLANTED MURINE GANGLIA

被引：30

作者：

LEIB, DA

RUFFNER, KL

HILDEBRAND, C

SCHAFFER, PA

WRIGHT, GE

COEN, DM

机构：

[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,TUMOR VIRUS GENET LAB,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115

[4] UNIV MASSACHUSETTS,SCH MED,DEPT PHARMACOL,WORCESTER,MA 01655

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 06期

关键词：

D O I：

10.1128/AAC.34.6.1285

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the frequency of reactivation compared with that of untreated controls.

引用

页码：1285 / 1286

页数：2

共 19 条

[11]

LEIST TP, 1989, J VIROL, V63, P4979

[12] DEMONSTRATION OF VIRAL THYMIDINE KINASE INHIBITOR AND ITS EFFECT ON DEOXYNUCLEOTIDE METABOLISM IN CELLS INFECTED WITH HERPES-SIMPLEX VIRUS [J].