INHIBITORY EFFECTS OF TEA EXTRACTS AND (-)-EPIGALLOCATECHIN GALLATE ON DNA-SYNTHESIS AND PROLIFERATION OF HEPATOMA AND ERYTHROLEUKEMIA-CELLS

被引：91

作者：

LEA, MA ^{[1
]}

XIAO, Q ^{[1
]}

SADHUKHAN, AK ^{[1
]}

COTTLE, S ^{[1
]}

WANG, ZY ^{[1
]}

YANG, CS ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,COLL PHARM,CANC RES LAB,PISCATAWAY,NJ 08855

来源：

CANCER LETTERS | 1993年 / 68卷 / 2-3期

关键词：

TEA; POLYPHENOL; (-)-EPIGALLOCATECHIN GALLATE; DNA SYNTHESIS; HEPATOMA; ERYTHROLEUKEMIA;

D O I：

10.1016/0304-3835(93)90151-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polyphenols extracted from green or black tea with ethyl acetate were strongly inhibitory for DNA synthesis in HTC rat hepatoma cells and DS19 mouse erythroleukemia cells at concentrations of 0.1 - 0.2 mg/ml. There was less inhibition with a subsequent black tea fraction extracted with butanol and with the residual water-soluble fraction. Although cell proliferation was inhibited by (-)-epigallocatechin gallate and the tea extracts, there were only marginal effects on differentiation of DS19 cells as judged by hemoglobin synthesis.

引用

页码：231 / 236

页数：6

共 16 条

[1] SITE-SPECIFIC DNA CLEAVAGE BY MAMMALIAN DNA TOPOISOMERASE-II INDUCED BY NOVEL FLAVONE AND CATECHIN DERIVATIVES
AUSTIN, CA
PATEL, S
ONO, K
NAKANE, H
FISHER, LM
[J]. BIOCHEMICAL JOURNAL, 1992, 282 : 883 - 889
[2] INHIBITORY EFFECT OF GREEN TEA ON TUMORIGENESIS BY CHEMICALS AND ULTRAVIOLET-LIGHT
CONNEY, AH
WANG, ZY
HUANG, MT
HO, CT
YANG, CS
[J]. PREVENTIVE MEDICINE, 1992, 21 (03) : 361 - 369
[3] A MODIFICATION OF THE BENZIDINE METHOD FOR MEASUREMENT OF HEMOGLOBIN IN PLASMA AND URINE
CROSBY, WH
FURTH, FW
[J]. BLOOD, 1956, 11 (04) : 380 - 383
[4] FIBACH E, 1977, CANCER RES, V37, P440
[5] SUPPRESSION OF GENOTOXICITY OF CARCINOGENS BY (-)-EPIGALLOCATECHIN GALLATE
HAYATSU, H
INADA, N
KAKUTANI, T
ARIMOTO, S
NEGISHI, T
MORI, K
OKUDA, T
SAKATA, I
[J]. PREVENTIVE MEDICINE, 1992, 21 (03) : 370 - 376
[6] DETECTION AND CHEMICAL-IDENTIFICATION OF NATURAL BIO-ANTIMUTAGENS - A CASE OF THE GREEN TEA FACTOR
KADA, T
KANEKO, K
MATSUZAKI, S
MATSUZAKI, T
HARA, Y
[J]. MUTATION RESEARCH, 1985, 150 (1-2): : 127 - 132
[7] KISSANE JM, 1958, J BIOL CHEM, V233, P184
[8] INHIBITORY EFFECTS OF OROTATE ON PRECURSOR INCORPORATION INTO NUCLEIC-ACIDS
LEA, MA
LUKE, A
ASSAD, A
AYYALA, S
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1990, 75 (01) : 49 - 59
[9] TEA COMPONENTS - ANTIMUTAGENIC AND ANTICARCINOGENIC EFFECTS
MUKHTAR, H
WANG, ZY
KATIYAR, SK
AGARWAL, R
[J]. PREVENTIVE MEDICINE, 1992, 21 (03) : 351 - 360
[10] DIFFERENTIAL INHIBITORY EFFECTS OF SOME CATECHIN DERIVATIVES ON THE ACTIVITIES OF HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE AND CELLULAR DEOXYRIBONUCLEIC AND RIBONUCLEIC-ACID POLYMERASES
NAKANE, H
ONO, K
[J]. BIOCHEMISTRY, 1990, 29 (11) : 2841 - 2845

← 1 2 →