INHIBITORY EFFECTS OF TEA EXTRACTS AND (-)-EPIGALLOCATECHIN GALLATE ON DNA-SYNTHESIS AND PROLIFERATION OF HEPATOMA AND ERYTHROLEUKEMIA-CELLS

被引：91

作者：

LEA, MA ^{[1
]}

XIAO, Q ^{[1
]}

SADHUKHAN, AK ^{[1
]}

COTTLE, S ^{[1
]}

WANG, ZY ^{[1
]}

YANG, CS ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,COLL PHARM,CANC RES LAB,PISCATAWAY,NJ 08855

来源：

CANCER LETTERS | 1993年 / 68卷 / 2-3期

关键词：

TEA; POLYPHENOL; (-)-EPIGALLOCATECHIN GALLATE; DNA SYNTHESIS; HEPATOMA; ERYTHROLEUKEMIA;

D O I：

10.1016/0304-3835(93)90151-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polyphenols extracted from green or black tea with ethyl acetate were strongly inhibitory for DNA synthesis in HTC rat hepatoma cells and DS19 mouse erythroleukemia cells at concentrations of 0.1 - 0.2 mg/ml. There was less inhibition with a subsequent black tea fraction extracted with butanol and with the residual water-soluble fraction. Although cell proliferation was inhibited by (-)-epigallocatechin gallate and the tea extracts, there were only marginal effects on differentiation of DS19 cells as judged by hemoglobin synthesis.

引用

页码：231 / 236

页数：6

共 16 条

[11] RICHON M, 1992, MOL CELLULAR APPROAC, P243
[12] PREVENTION OF CYTO-TOXICITY AND INHIBITION OF INTERCELLULAR COMMUNICATION BY ANTIOXIDANT CATECHINS ISOLATED FROM CHINESE GREEN TEA
RUCH, RJ
CHENG, SJ
KLAUNIG, JE
[J]. CARCINOGENESIS, 1989, 10 (06) : 1003 - 1008
[13] PROLIFERATION IS REQUIRED FOR INDUCTION OF TERMINAL DIFFERENTIATION OF FRIEND-ERYTHROLEUKEMIA CELLS
SPRIGGS, LL
HILL, SM
JETER, JR
[J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1992, 70 (07): : 555 - 564
[14] EFFECT OF (-)-EPIGALLOCATECHIN GALLATE, THE MAIN CONSTITUENT OF GREEN TEA, ON LUNG METASTASIS WITH MOUSE B16 MELANOMA CELL-LINES
TANIGUCHI, S
FUJIKI, H
KOBAYASHI, H
GO, H
MIYADO, K
SADANO, H
SHIMOKAWA, R
[J]. CANCER LETTERS, 1992, 65 (01) : 51 - 54
[15] INDUCTION OF TYROSINE ALPHA-KETOGLUTARATE TRANSAMINASE BY STEROID HORMONES IN A NEWLY ESTABLISHED TISSUE CULTURE CELL LINE
THOMPSON, EB
TOMKINS, GM
CURRAN, JF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 56 (01) : 296 - &
[16] WANG ZY, 1992, CANCER RES, V52, P6657

← 1 2 →